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KMID : 1037520140300020049
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Vascular Specialist International
2014 Volume.30 No. 2 p.49 ~ p.55
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Occurrence and Prognosis of Symptomatic Venous Thromboembolism in Colorectal Cancer Surgery Patients
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Kim Dae-Sik
Park Keun-Myoung
Won Yong-Sung
Kim Jang-Yong
Lee Jin-Kwon
Kim Jun-Gi
Oh Seong-Taek
Jung Sang-Seol
Kang Won-Kyung
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Abstract
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Purpose: Colorectal cancer (CRC) has a high risk for postoperative thromboembolic complications such as venous thromboembolism (VTE) compared to other surgical diseases, but the relationship between VTE and CRC in Asian patients remains poorly understood. The present study examined the incidence of symptomatic VTE in Korean patients who underwent surgery for CRC. We also identified risk factors, incidence and survival rate for VTE in these patients.
Materials and Methods: The patients were identified from the CRC database treated from January 2011 to December 2012 in a single institution. These patients were classified into VTE and non-VTE groups, their demographic features were compared, and the factors which had significant effects on VTE and mortality between the two groups were analyzed.
Results: We analyzed retrospectively a total of 840 patients and the incidence of VTE was 3.7% (31 patients) during the follow-up period (mean, 17.2 months). Histologic subtype (mucinous adenocarcinoma) and previous history of VTE affected the incidence of VTE on multivariate analysis. There was a statistically significant difference in survival rate between the VTE and non-VTE group, but VTE wasn’t the factor affecting survival rate on multivariate analysis. Comparing differences in survival rate for each pathologic stage, there was only a significant difference in stage II patients.
Conclusion: Among CRC patients after surgery, the incidence of VTE was app-roximately 3% within 1 year and development of VTE wasn’t a significant risk fac-tor for death in our study but these findings are not conclusive due to our small sample size.
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KEYWORD
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Venous thromboembolism, Colorectal cancer, Survival rate
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